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IL-21 Protein, Rat

IL-21 Protein, Rat

货号: UA040233
价格: 880
规格: 10μg
介绍: -
其他: -
产品规格

  • 物种

    Rat

  • 分子别名

    Interleukin-21, IL-21

  • Accession

    A3QPB9

  • 表达序列

    His18-Ser146

  • 表达宿主

    E.coli

  • 分子量

    15kDa

  • 纯度

    ＞95% by SDS-PAGE&RP-HPLC

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    No Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    20mM Tris, 400mM NaCl, pH8.0

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.J Immunotoxicol. 2016 May;13(3):274-85.
    2.Epub 2015 Oct 28. 2.Front Cell Infect Microbiol. 2019 Dec 4:9:401.
    3.eCollection 2019. 3.Med Oncol. 2023 May 30;40(7):191.

  • 稀释度

背景介绍

  • Cytokines are considered important factors in the modulation of various immune responses. Among them, interleukin (IL)-21 is one of the major immune modulators, adjusting various immune responses by affecting various immune cells. It has been suggested that IL-21 may enhance autoimmunity through different mechanisms, such as development and activation of helper T (TH)-17 and follicular helper T (TFH) cells, activation of natural killer (NK) cells, enhancing B-cell differentiation and antibody secretion and suppression of regulatory T (Treg) cells. Actually IL-21 is a pleiotropic cytokine whose functions in protection and immunopathology during parasitic diseases have been explored in limited ways, and it has been revealed to elicit antitumor-immune responses in several tumor models.

  • 生物活性JSON

    • Measured by its ability to enhance IFN-gamma secretion in NK-92 human natural killer lymphoma cells. The EC50 for this effect is less than 15ng/mL.

  • 电泳JSON

    • 2μg (R: reducing condition, N: non-reducing condition).

  • 反相高效液相色谱JSON(RP-HPLC)