您现在的位置：首页 - 产品中心 - 免疫学 - 抗体

CD300f/LMIR3/IREM-1 His Tag Protein, Human

货号: UA010872

价格: 1300

规格: 25μg

介绍: -

其他: -

产品规格

物种

Human
分子别名

CD300f, LMIR3, CLM1, IGSF13, IREM-1, NKIR
Accession

Q8TDQ1-1
表达序列

Thr20-Ser156, with C-terminal His
表达宿主

HEK293
分子量

20-35kDa (Reducing)
纯度

＞95% by SDS-PAGE
内毒素含量

<0.1EU/μg
标记

Unconjugated
标签

His Tag
性状

Lyophilized Powder
缓冲体系

1*PBS, PH7.4, 5% trehalose
溶解方法

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
文献引用

Clark, G.J. et al. (2009) Trends Immunol. 30:209. Sui, L. et al. (2004) Biochem. Biophys. Res. Commun. 319:920. Alvarez-Errico, D. et al. (2004) Eur. J. Immunol. 34:3690. Korver, W. et al. (2009) Leukemia 23:1587.

背景介绍

LMIR3, also known as CD300f, CD300LF, IREM-1, CLM-1, IgSF13, DIgR1, and MAIR-V, is a 50-60 kDa glycoprotein member of the immunoglobulin superfamily. Human LMIR3 consists of a 137 amino acid (aa) extracellular domain (ECD) with one Ig-like V-type domain, a 21 aa transmembrane segment, and a 113 aa cytoplasmic domain that contains multiple immunoreceptor tyrosine-based inhibitory motifs (ITIMs) or ITIM-like sequences. Within the ECD, human LMIR3 shares 43% aa sequence identity with mouse and rat LMIR3. LMIR3 is expressed on the surface of dendritic cells, monocytes, granulocytes, and mast cells as well as on acute myeloid leukemia (AML) blasts. LMIR3 is up-regulated on monocytes surrounding experimentally-induced spinal cord demyelination and functions as a negative regulator of inflammation in the CNS.