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Biotinylated CLEC12A/MICL/CLL-1 Avi&His Tag Protein, Human

货号: UA010900

价格: 1420

规格: 25μg

介绍: -

其他: -

产品规格

物种

Human
分子别名

CLL1, DCAL2
Accession

Q5QGZ9-2
表达序列

His65-Ala265, with N-terminal His and Avitag
表达宿主

HEK293
分子量

35-45kDa (Reducing)
纯度

＞95% by SDS-PAGE
内毒素含量

<1EU/μg
性状

Lyophilized Powder
缓冲体系

PBS, pH7.4.
溶解方法

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
文献引用

1. Vitry, J.; Paré, G.; Murru,A.; Charest-Morin, X.; Maaroufi, H.;McLeish, K.R.; Naccache, P.H.;Fernandes, M.J. Regulation of the Expression, Oligomerisation and Signaling of the Inhibitory Receptor CLEC12A by Cysteine Residues in the Stalk Region. Int. J. Mol. Sci. 2021,22, 10207.

背景介绍

Clec12a (also called myeloid inhibitory C-type lectin-like receptor, MICL) was originally described as an ITIM-containing inhibitory CLR expressed by human granulocytes and monocytes. It was suggested that Clec12a recognizes some endogenous ligands as soluble Clec12a could bind to single-cell suspensions isolated from various murine tissues. CLEC12A is a myeloid lineage antigen that is highly expressed by AML cells and LSCs, but not expressed by normal hematopoietic stem cells (HSCs), thus minimizing off-target toxicity.