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GDF-5/BMP-14 Protein, Human

GDF-5/BMP-14 Protein, Human

货号: UA040209
价格: 460
规格: 10μg
介绍: -
其他: -
产品规格

  • 物种

    Human

  • 分子别名

    BMP14, CDMP1, LAP-4, LPS-associated protein 4

  • Accession

    P43026

  • 表达序列

    Ala382-Arg501

  • 表达宿主

    E.coli

  • 分子量

    28kDa (Non-reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 活性

    ＜0.2μg/mL

  • 标记

    Unconjugated

  • 标签

    No Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    50mM HAc, pH2.9

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Jin L, Li X. Growth differentiation factor 5 regulation in bone regeneration. Curr Pharm Des. 2013;19(19):3364-73.

  • 稀释度

背景介绍

  • Human growth differentiation factor 5 (GDF5) is one of the bone morphogenetic proteins (BMPs) belonging to the transforming growth factor β (TGF-β) superfamily. It has commercial value as a therapeutic protein because of its ability to induce cartilage and bone formation, and angiogenesis in adult animals. This protein regulates the development of numerous tissue and cell types, including cartilage, joints, brown fat, teeth, and the growth of neuronal axons and dendrites. Mutations of GDF5 are associated with several human and animal diseases that are characterized by skeletal deformity such as short digits and short limbs.

  • 生物活性JSON

    • Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The EC50 for this effect is less than 0.2μg/mL.

  • 电泳JSON

    • 1μg (R: reducing condition, N: non-reducing condition).