Ser113-Ala271
18kDa
50mM Tris,300mM NaCl,0.2M Arginine, pH8.0
Reconstitute at 0.05-0.3 mg/ml according to the size in ultrapure water after rapid centrifugation
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
1.Nicklin MJ,et al. (1994) A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes. Genomics. 19(2):382-4.
2.March CJ, et al. (1985) Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. Nature. 315(6021):641-7.
3.Bankers-Fulbright JL, et al. (1996) Interleukin-1 signal transduction. Life Sci. 59(2):61-83.
4.Dinarello CA, et al. (1997) Induction of interleukin-1 and interleukin-1 receptor antagonist. Semin Oncol. 24 (3 Suppl 9):S9-81-S9-93.
IL-1 alpha（IL-1α） is a member of the interleukin 1 cytokine family. IL-1α control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. IL-1α is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. It is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. IL-1 alpha stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity.
Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells.The EC50 for this effect is less than 6pg/ml.
1μg (R: reducing condition, N: non-reducing condition).
Protein A Chip captured IL-1 RII/CD121b Fc Chimera Protein, Human (Cat. No. UA011086), can bind IL-1α, Human (Cat. No. UA040204) with an affinity constant of 2.76μM as determined in SPR assay.
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