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Fc γ RIIIb/CD16b(NA1) His Tag Protein, Human

Fc γ RIIIb/CD16b(NA1) His Tag Protein, Human

货号: UA020006
价格: 1800
规格: 50μg
介绍: -
其他: -
产品规格

  • 物种

    Human

  • 分子别名

    Fc γ RIIIb, CD16b(NA1);Low affinity immunoglobulin gamma Fc region receptor III-B, Fc-gamma RIII-beta, FcR-10, IgG Fc receptor III-1, FCG3, FCGR3, CD16b and FCGR3B.

  • Accession

    O75015

  • 表达序列

    Gly17-Ser200(NA1), with C-terminal His

  • 表达宿主

    HEK293

  • 分子量

    33-40 kDa(Reducing)

  • 纯度

    ＞95%, by SDS-PAGE under reducing conditions

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation .

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 稀释度

背景介绍

  • IgG Fc receptor (Fc γ R) is a member of the Ig superfamily, which plays a role in activating or inhibiting immune response. Human Fc γ Rs is identified as three types: RI (CD64), RII (CD32) and RIII (CD16). CD16 is a low-affinity Fc receptor, which has been identified as Fc receptor Fc γ RIII (a (CD16a) and Fc γ RIIIb (CD16b). These receptors bind to the Fc portion of the IgG antibody and are encoded by two different highly homologous genes in a cell type-specific manner. CD16b, also known as FCGR3b and FCG3b, is specifically expressed by neutrophils and stimulated eosinophils. CD16b is a low affinity receptor of immunoglobulin Fc γ region. CD16b binds composite or aggregated IgG and monomer IgG. CD16b could not mediate antibody-dependent cytotoxicity and phagocytosis.

  • 生物活性JSON

    • Anti-His antibody Immobilized on CM5 Chip captured CD16b(NA1) His Tag, Human (Cat. No. UA020006), can bind IgG1-Fc (UA050001) with an affinity constant of 9.237 μM as determined in SPR assay (Biacore T200).

  • 电泳JSON

    • Fc γ RⅢb/CD16b(NA1) His Tag, Human，2 μg on SDS-PAGE under reducing and Non-reducing condition. The purity is greater than 95%.

  • SPR

    • Anti-His antibody Immobilized on CM5 Chip captured Fc γ RIIIb/CD16b(NA1) His Tag, Human (Cat. No. UA020006), can bind Rituximab with an affinity constant of 1.93 μM as determined in SPR assay.