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Fc γ RIIA/CD32a His Tag Protein, Cynomolgus

Fc γ RIIA/CD32a His Tag Protein, Cynomolgus

货号: UA020013
价格: 1800
规格: 50μg
介绍: -
其他: -
产品规格
  • 物种

    Cynomolgus
  • 分子别名

    Low affinity immunoglobulin gamma Fc region receptor II-a, IgG Fc receptor II-a, CDw32, Fc-gamma RII-a, Fc-gamma-RIIa, FcRII-a, CD32, FCGR2A, FCG2, FCGR2A1, IGFR2
  • Accession

    Q8SPW4-1
  • 表达序列

    Gln28-Pro208, with C-terminal His
  • 表达宿主

    HEK293
  • 分子量

    30-35kDa(Reducing)
  • 纯度

    >95%, by SDS-PAGE under reducing conditions
  • 内毒素含量

    <0.1EU/μg
  • 标记

    Unconjugated
  • 标签

    His Tag
  • 性状

    Lyophilized Powder
  • 缓冲体系

    PBS, pH7.4
  • 溶解方法

    Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation .
  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.
  • 稀释度

背景介绍
  • IgG Fc receptor (Fc γ R) is a member of the Ig superfamily, which plays a role in activating or inhibiting immune response. Human Fc γ Rs is identified as three subtypes: RI (CD64), RII (CD32) and RIII (CD16). There are three human Fc γ RII / CD32 genes (A, B and C), two crab eating monkeys (An and B), and one Fc γ RII B in mice. Fc γ RIIA of cynomolgus monkey consists of extracellular domain, transmembrane domain and cytoplasmic domain. The extracellular domain includes two IgG domains. The Fc γ RIIA protein of crab-eating monkey has 89% homology with human Fc γ RIIA. CD32a is expressed in a variety of immune cells such as macrophages, neutrophils and platelets. When it binds to ligands, it initiates inflammatory responses, including cytolysis, phagocytosis, degranulation and production of cytokines. This response can be regulated by co-expression of inhibitory receptors such as CD32B.

  • 生物活性JSON

    • Anti-His antibody Immobilized on CM5 Chip captured CD32a His Tag, Cynomolgus (Cat. No. UA020013), can bind IgG1-Fc (UA050001) with an affinity constant of 14.50 μM as determined in SPR assay (Biacore T200).
  • 电泳JSON

    • Fc γ RIIA/CD32a His Tag, Cynomolgus,1μg on SDS-PAGE under reducing and Non-reducing condition. The purity is greater than 95%.