Pro 20-Lys 291 with His Tag at C-Terminus
PBS, pH7.4
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
1.Wang SY, An WH, Wang ZS, Wang WL, Zhang B, Xu KL, Guo SL, Gao M, Li B, Huang L, Tian HH, Guo WY, Wang HR. Incidentally cured psoriasis in a patient with refractory/relapsed diffuse large B-cell lymphoma receiving CD19 CAR-T cell therapy: a case report. Front Immunol. 2024 Oct 24; 15: 1418768.
CD19, also known as B-lymphocyte antigen or Cluster of Differentiation 19, is a single-pass type I membrane protein that contains two Ig-like C2-type (immunoglobulin-like) domains. It is expressed on follicular dendritic cells and B cells, being present from the earliest recognizable B-lineage cells during development to B-cell blasts, but is lost upon maturation to plasma cells. CD19 primarily functions as a B cell co-receptor in conjunction with CD21 and CD81. Upon activation, the cytoplasmic tail of CD19 becomes phosphorylated, leading to binding by Src-family kinases and recruitment of PI-3 kinase. Mutations in the CD19 gene are associated with severe immunodeficiency syndromes, characterized by diminished antibody production. CD19 has been shown to interact with CD81, CD82, Complement receptor 2, and VAV2.
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