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Von Willebrand Factor Recombinant Rabbit mAb (S-663-116)

Von Willebrand Factor Recombinant Rabbit mAb (S-663-116)

货号: S0B0869
价格: 600
规格: 25μl
介绍: -
其他: -
产品规格
  • 宿主来源

    Rabbit
  • 抗原名称

    Von Willebrand Factor
  • 分子别名

    VWF
  • 免疫原

    Synthetic Peptide
  • 细胞定位

    Secreted
  • Accession

    P04275
  • 克隆号

    S-663-116
  • 抗体类型

    Recombinant mAb
  • 抗体同种型

    IgG
  • 应用

    WB
  • 反应种属 ?

    Ms
  • 纯化方式

    Protein A
  • 浓度

    0.5 mg/ml
  • 标记

    Unconjugated
  • 性状

    Liquid
  • 缓冲体系

    PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
  • 储存条件

    12 months from date of receipt / reconstitution, -20 °C as supplied

稀释度
应用 稀释度
WB 1:1000
背景介绍
  • Von Willebrand Factor (VWF) is a glycoprotein encoded by the gene located on the short arm of chromosome 12. Under normal physiological conditions, VWF is mainly produced by endothelial cells and stored in Weibel-Palade bodies, while the VWF produced by megakaryocytes is stored in platelet granules. When there is an injury to the blood vessels, VWF acts as a bridge that enables platelets to adhere to collagen fibers, leading to the formation of a blood clot and achieving hemostasis. The concentration of VWF in normal human plasma is about 10mg/L. It can increase in response to endothelial cell stimulation or damage and during periods of physiological stress. Elevated levels of VWF are associated with an increased risk of thrombotic diseases, and certain mutations in the VWF gene can lead to von Willebrand disease (vWD), a bleeding disorder characterized by a deficiency or dysfunction of VWF.

  • 免疫印迹

    • WB result of Von Willebrand Factor Recombinant Rabbit mAb
      Primary antibody: Von Willebrand Factor Recombinant Rabbit mAb at 1/1000 dilution
      Lane 1: mouse lung lysate 20 µg
      Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 309 kDa
      Observed MW: 280 kDa