Glu36-Asp161 with His & Avi Tag at C-Terminus
PBS PH7.4 5% trehalose
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Liu M, Wu F, Duan B, Zhang Y, Wang W, Chen Z, Sun Y, Zhang G, Wang Y, Sun Y, Ouyang Y, Li G. Distinct immune memory induced by SARS-CoV-2 in convalescent liver transplant recipients. Front Immunol. 2025 Apr 2;16:1420150.
CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4), also known as CD152 (Cluster of Differentiation 152 is), a protein receptor that downregulates immune responses. As a member of the immunoglobulin superfamily, CTLA-4 is expressed on the surface of helper T cells and delivers an inhibitory signal to regulate T cell activity. Structurally, the protein comprises an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternative splice variants of CTLA-4 produce different isoforms, including a soluble form.
CTLA-4 shares homology with the T-cell co-stimulatory protein CD28, and both molecules interact with CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells. However, they perform opposing functions: while CD28 provides a stimulatory signal, CTLA-4 delivers an inhibitory signal, making it a critical checkpoint in immune regulation. Intracellular CTLA-4 is also found in regulatory T cells and plays a role in their function.
Fusion proteins incorporating CTLA-4, such as CTLA4-Ig, have been utilized in clinical trials for conditions like rheumatoid arthritis, highlighting its potential in immunotherapy.
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