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IKKα Rabbit polyclonal antibody

货号: S0B0662

价格: 600

规格: 25μl

介绍: -

其他: -

产品规格

宿主来源

Rabbit
分子别名

Inhibitor of nuclear factor kappa-B kinase subunit alpha, I-kappa-B kinase alpha, IKK-A, IKK-alpha, IkBKA, IkappaB kinase, Conserved helix-loop-helix ubiquitous kinase, I-kappa-B kinase 1 (IKK-1; IKK1), Nuclear factor NF-kappa-B inhibitor kinase alpha (NFKBIKA), Transcription factor 16 (TCF-16), CHUK, IKKA, TCF16
免疫原

Synthetic Peptide
细胞定位

Cytoplasm, Nucleus
Accession

O15111
抗体类型

Polyclonal antibody
抗体同种型

IgG
应用

WB, IP
反应种属 ?

Hu, Ms, Rt
纯化方式

Immunogen Affinity
浓度

0.5 mg/ml
标记

Unconjugated
性状

Liquid
缓冲体系

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
储存条件

12 months from date of receipt / reconstitution, -20 °C as supplied

稀释度

应用	稀释度
WB	1:1000
IP	1:50

背景介绍

IKKα, a member of the IKK family, possesses two kinase domains responsible for regulating the phosphorylation and degradation of IκB proteins. It specifically phosphorylates certain residues of IκB proteins (such as Ser32 and Ser36), leading to the degradation of IκB and subsequent activation of the NF-κB signaling pathway. IKKα plays a significant role in the immune system, particularly in regulating T-cell functions. It controls T-cell metabolism and proliferation, thereby influencing immune responses. Additionally, IKKα modulates the synthesis of cytokines, regulating interactions among immune cells. Studies have indicated abnormal expression or activity of IKKα in various cancers. Targeting IKKα represents a potential new strategy for cancer therapy. IKKα is also involved in the pathogenesis of multiple inflammatory diseases. Inhibitors of IKKα can alleviate inflammatory reactions, offering new avenues for treating these conditions.