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Anti-HER2 Monoclonal Antibody(Pertuzumab)

Anti-HER2 Monoclonal Antibody(Pertuzumab)

货号: S0B0568
价格: 1850
规格: 1mg
介绍: -
其他: -
产品规格
  • 宿主来源

    Human
  • 分子别名

    Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein (MLN 19), Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2, CD340, ERBB2, MLN19, NEU, NGL
  • Accession

    P04626
  • 克隆号

    S-SC018
  • 抗体类型

    Recombinant mAb
  • 抗体同种型

    IgG1,k
  • 应用

    Blocking of HER2 signaling Functional assays
  • 纯化方式

    Protein A
  • 浓度

    2 mg/ml
  • 内毒素含量

    <1EU/mg
  • 标记

    Unconjugated
  • 性状

    Liquid
  • 缓冲体系

    PBS pH7.4, containing no preservative
  • 储存条件

    12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

稀释度
应用 稀释度
ELISA 1.221-5000 ng/ml
背景介绍
  • Pertuzumab is a monoclonal antibody used in combination with trastuzumab and docetaxel for the treatment of metastatic HER2-positive breast cancer; it also used in the same combination as a neoadjuvant in early HER2-positive breast cancer. It is the first-in-class of a kind of drug called a "HER dimerization inhibitor" — it inhibits the dimerization of HER2 with other HER receptors, which prevents them from signalling in ways that promote cell growth and proliferation.

  • ELISA

    • Immobilized human Her2 at 0.5 μg/ml (50μL/well) can bind to Pertuzumab with a linear range of 1.221 ng/ml to 5 μg/ml.