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Alexa Fluor® 647 Mouse Anti-Human CD73 Antibody (S-715-115)

Alexa Fluor® 647 Mouse Anti-Human CD73 Antibody (S-715-115)

货号: S0B0190
价格: 650
规格: 20T
介绍: -
其他: -
产品规格

  • 宿主来源

    Mouse

  • 抗原名称

    CD73

  • 分子别名

    5'-nucleotidase, 5'-NT, 5'-deoxynucleotidase, Ecto-5'-nucleotidase, IMP-specific 5'-nucleotidase, Thymidylate 5'-phosphatase, NT5E, NT5, NTE

  • 免疫原

    Recombinant Protein

  • 细胞定位

    Cell membrane

  • Accession

    P21589

  • 克隆号

    S-715-115

  • 抗体类型

    Mouse mAb

  • 抗体同种型

    IgG2b,k

  • 应用

    FCM

  • 反应种属 ?

    Hu

  • 纯化方式

    Protein A

  • 浓度

    50μg/ml

  • 标记

    Alexa Fluor® 647

  • 性状

    Liquid

  • 缓冲体系

    PBS, 0.1% BSA, 0.01% Proclin 300

  • 储存条件

    12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
稀释度
应用 稀释度
FCM 5 μl per million cells in 100μl volume
背景介绍

  • NT5E (CD73) is a surface enzyme which is expressed on multiple cells. This enzyme mediates the gradual hydrolysis of the autocrine and paracrine danger signals of ATP and ADP to anti-inflammatory adenosine. Immune suppression mediated by adenosinergic pathways is very important for maintaining immune system homeostasis. Immune suppressive functions of T regulatory cells are also dependent on CD73 expression. CD73 also occurs on anergic CD4 + T cells, thereby maintaining self-tolerance to healthy tissues as well as protecting the fetus from the mother's immune system during pregnancy.