PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
12 months from date of receipt / reconstitution, -20 °C as supplied
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| WB | 1:1000 | Hu, Ms |
MYPT1, or Myosin Phosphatase Targeting Subunit 1, is a regulatory subunit that binds to the catalytic subunit of protein phosphatase 1 (PP1) to form the myosin phosphatase (MP) complex. This complex is crucial for the dephosphorylation of myosin light chains, which regulates muscle contraction and relaxation. MYPT1 acts as a tumor suppressor in various cancers. It inhibits tumor progression by regulating gene expression and modulating the activity of oncogenic pathways. For instance, in prostate cancer, reduced MYPT1 expression is associated with increased tumor angiogenesis and poor patient prognosis. Similarly, in non-small cell lung cancer, MYPT1 regulated by miR-19b-3p inhibits tumor progression.
WB result of MYPT1 Recombinant Rabbit mAb
Primary antibody: MYPT1 Recombinant Rabbit mAb at 1/1000 dilution
Lane 1: HeLa whole cell lysate 20 µg
Lane 2: Caco-2 whole cell lysate 20 µg
Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
Predicted MW: 115 kDa
Observed MW: 140 kDa
WB result of MYPT1 Recombinant Rabbit mAb
Primary antibody: MYPT1 Recombinant Rabbit mAb at 1/1000 dilution
Lane 1: NIH/3T3 whole cell lysate 20 µg
Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
Predicted MW: 115 kDa
Observed MW: 140 kDa
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