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HDAC1 Recombinant Rabbit mAb (HRP Conjugate) (SDT-310-72)

HDAC1 Recombinant Rabbit mAb (HRP Conjugate) (SDT-310-72)

货号: S0B1834
价格: 720
规格: 25μl
介绍: -
其他: -
产品规格
  • 宿主来源

    Rabbit
  • 抗原名称

    HDAC1
  • 分子别名

    Histone deacetylase 1; HD1; Protein deacetylase HDAC1
  • 免疫原

    Synthetic Peptide
  • 细胞定位

    Nucleus
  • Accession

    Q13547
  • 克隆号

    SDT-310-72
  • 抗体类型

    Recombinant mAb
  • 抗体同种型

    IgG
  • 应用

    WB
  • 反应种属 ?

    Hu, Ms, Rt
  • 阳性样本

    HeLa, Jurkat, K562, NIH/3T3, C6
  • 预测反应种属
    (反应种属缩写表)

    Bv
  • 纯化方式

    Protein A
  • 浓度

    1 mg/ml
  • 标记

    HRP
  • 性状

    Liquid
  • 缓冲体系

    PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

  • 储存条件

    12 months from date of receipt / reconstitution, -20 °C as supplied

稀释度
应用 稀释度 推荐种属
WB 1:10000 Hu, Ms, Rt
背景介绍
  • Histone deacetylase 1 (HDAC1) is a key enzyme involved in the regulation of gene expression through the deacetylation of histone and non-histone proteins. As a zinc-dependent deacetylase, HDAC1 removes acetyl groups from lysine residues on histones, thereby tightening chromatin structure and inhibiting gene transcription. It is a component of several multiprotein complexes, such as the NuRD complex, which are involved in chromatin remodeling and transcriptional repression. HDAC1 plays a crucial role in various cellular processes, including cell cycle progression, differentiation, and development. In cancer, HDAC1 is often overexpressed and contributes to tumor progression by promoting cell proliferation and survival. For example, in colorectal cancer, HDAC1 enhances cell survival and proliferation in an ATG16L-dependent manner. Additionally, HDAC1 overexpression in cancer cells can be regulated by transcription factors like Sp1 and Sp3, which bind to the HDAC1 promoter and recruit other epigenetic modulators. In neurodegenerative diseases such as Alzheimer's disease, HDAC1 has been implicated in the regulation of oxidative DNA damage repair and synaptic function. Studies have shown that HDAC1 activity may be involved in the pathogenesis of Alzheimer's disease through its effects on DNA repair mechanisms and gene expression. HDAC1 is also a potential therapeutic target for neurological disorders, as HDAC inhibitors have shown promise in preclinical studies for treating conditions like Huntington's disease and Parkinson's disease.

  • 免疫印迹

    • WB result of HDAC1 Recombinant Rabbit mAb (HRP Conjugate)
      Primary antibody: HDAC1 Recombinant Rabbit mAb (HRP Conjugate) at 1/10000 dilution
      Lane 1: HeLa whole cell lysate 20 µg
      Lane 2: Jurkat whole cell lysate 20 µg
      Lane 3: K562 whole cell lysate 20 µg
      Predicted MW: 55 kDa
      Observed MW: 62 kDa

    • WB result of HDAC1 Recombinant Rabbit mAb (HRP Conjugate)
      Primary antibody: HDAC1 Recombinant Rabbit mAb (HRP Conjugate) at 1/10000 dilution
      Lane 1: NIH/3T3 whole cell lysate 20 µg
      Predicted MW: 55 kDa
      Observed MW: 62 kDa

    • WB result of HDAC1 Recombinant Rabbit mAb (HRP Conjugate)
      Primary antibody: HDAC1 Recombinant Rabbit mAb (HRP Conjugate) at 1/10000 dilution
      Lane 1: C6 whole cell lysate 20 µg
      Predicted MW: 55 kDa
      Observed MW: 62 kDa