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Rat Anti-Mouse CD185 Antibody (S-R600)

Rat Anti-Mouse CD185 Antibody (S-R600)

货号: S0B5044
价格: 600
规格: 50μl
介绍: -
其他: -
产品规格
  • 宿主来源

    Rat
  • 抗原名称

    Mouse CD185
  • 分子别名

    C-X-C chemokine receptor type 5; CXC-R5; CXCR-5; Burkitt lymphoma receptor 1 homolog; Cxcr5; Blr1; Gpcr6
  • 细胞定位

    Cell membrane
  • Accession

    Q04683
  • 克隆号

    S-R600
  • 抗体类型

    Rat mAb
  • 抗体同种型

    IgG2b,k
  • 应用

    FCM
  • 反应种属 ?

    Ms
  • 阳性样本

    C57BL/6 mouse splenocytes
  • 纯化方式

    Protein G
  • 浓度

    2 mg/ml
  • 标记

    Unconjugated
  • 性状

    Liquid
  • 缓冲体系

    PBS pH7.4

  • 储存条件

    12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

稀释度
应用 稀释度 推荐种属
FCM 1:200 Ms
背景介绍
  • CD185, also known as CXCR5 (C-X-C motif chemokine receptor 5), is a seven-transmembrane G protein-coupled receptor primarily expressed on mature B cells, follicular helper T cells (Tfh), and certain memory T cell subsets. It is essential for lymphocyte trafficking, particularly in directing T cells to B cell follicles within germinal centers in response to its ligand, CXCL13. CD185 plays a critical role in B cell maturation and the formation of high-affinity antibodies by facilitating interactions between Tfh cells and B cells. Additionally, it is involved in the regulation of neural stem cells and neuronal regeneration.

  • 流式分析

    • Flow cytometric analysis of C57BL/6 mouse splenocytes labelling Mouse CD185 antibody at 1/200 (1 μg) dilution/ (Right panel) compared with a Rat IgG2b, κ Isotype Control / (Left panel). Goat Anti-Rat IgG Alexa Fluor® 647 was used as the secondary antibody. Then cells were stained with CD19 - Brilliant Violet 421™ Antibody separately.