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OGN Recombinant Rabbit mAb (S-245-327)

OGN Recombinant Rabbit mAb (S-245-327)

货号: S0B1353
价格: 600
规格: 50μl
介绍: -
其他: -
产品规格

  • 宿主来源

    Rabbit

  • 抗原名称

    OGN

  • 分子别名

    Mimecan; Osteoglycin; Osteoinductive factor (OIF); OIF; SLRR3A

  • 免疫原

    Synthetic Peptide

  • 细胞定位

    Secreted, Extracellular space

  • Accession

    P20774

  • 克隆号

    S-245-327

  • 抗体类型

    Recombinant mAb

  • 抗体同种型

    IgG

  • 应用

    WB

  • 反应种属 ?

    Hu, Ms, Rt

  • 阳性样本

    MCF7, HeLa, mouse skeletal muscle, mouse blood vessel, mouse skin, rat skeletal muscle, rat blood vessel, rat skin

  • 预测反应种属
    (反应种属缩写表)

    Or

  • 纯化方式

    Protein A

  • 浓度

    0.5 mg/ml

  • 标记

    Unconjugated

  • 性状

    Liquid

  • 缓冲体系

    PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

  • 储存条件

    12 months from date of receipt / reconstitution, -20 °C as supplied

稀释度
应用 稀释度 推荐种属
WB 1:1000 Hu, Ms, Rt
背景介绍

  • OGN (Osteoglycin), also known as Mimecan or SLRR3A, is a member of the small leucine-rich proteoglycan (SLRP) family and a glycosylated protein involved in the development of the extracellular matrix (ECM). It functions as a growth factor that induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2 and may regulate osteoblast differentiation. OGN is expressed in various tissues and is implicated in multiple biological processes, including fibrosis, tumorigenesis, and cardiovascular events. High expression of OGN has been associated with elevated heart left ventricular mass and may play a role in the progression of certain cancers, such as pancreatic cancer, by targeting ID4. Additionally, OGN is detected in blood through mass spectrometry and proximity extension assays, indicating its potential as a biomarker in diseases like pediatric retinoblastoma.

  • 免疫印迹

    • WB result of OGN Recombinant Rabbit mAb
      Primary antibody: OGN Recombinant Rabbit mAb at 1/1000 dilution
      Lane 1: MCF7 whole cell lysate 20 µg
      Lane 2: HeLa whole cell lysate 20 µg
      Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 34 kDa
      Observed MW: 40 kDa

    • WB result of OGN Recombinant Rabbit mAb
      Primary antibody: OGN Recombinant Rabbit mAb at 1/1000 dilution
      Lane 1: mouse skeletal muscle lysate 20 µg
      Lane 2: mouse blood vessel lysate 20 µg
      Lane 3: mouse skin lysate 20 µg
      Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 34 kDa
      Observed MW: 40, 25 kDa

    • WB result of OGN Recombinant Rabbit mAb
      Primary antibody: OGN Recombinant Rabbit mAb at 1/1000 dilution
      Lane 1: rat skeletal muscle lysate 20 µg
      Lane 2: rat blood vessel lysate 20 µg
      Lane 3: rat skin lysate 20 µg
      Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 34 kDa
      Observed MW: 40, 25 kDa