PBS pH7.4, 0.03% Proclin 300
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| FCM | 5μl per million cells in 100μl volume | Hu |
CD16, also known as FcγRIII, is a low-affinity IgG receptor expressed on various immune cells, including natural killer (NK) cells, monocytes, macrophages, and neutrophils. As a member of the immunoglobulin superfamily, CD16 plays a crucial role in immune responses by binding to the Fc portion of IgG antibodies. This interaction triggers several important immune functions such as phagocytosis, respiratory burst, and antibody-dependent cellular cytotoxicity (ADCC), which are vital for defending against pathogens and cancer cells. CD16 exists in two forms, CD16a and CD16b, with CD16a being predominantly found on NK cells and monocytes, while CD16b is primarily expressed on neutrophils. Its ability to activate NK cells and enhance their cytotoxicity against target cells makes CD16 a significant target in cancer immunotherapy and antibody drug development.
Flow cytometric analysis of Human CD16 expression on human peripheral blood. Human peripheral blood was stained with biotin Isotype Control (Left panel) or SDT APC Mouse Anti-Human CD11a antibody (Right panel) at 5μl/test followed by Sav-iFluor 488. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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