PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| FCM | 5 μl per million cells in 100μl volume | Hu |
CD206, also known as the mannose receptor (MRC1), is a highly glycosylated type I transmembrane protein primarily expressed on the surface of macrophages and dendritic cells. It plays a crucial role in the innate immune response by mediating the endocytosis and phagocytosis of various pathogens, including bacteria, fungi, and viruses, through its ability to bind to mannan-coated cell walls or envelopes. CD206 is a marker for alternatively activated M2 macrophages, which are characterized by their anti-inflammatory phenotype and are involved in wound healing and immune tolerance. In the context of cancer, tumor-associated macrophages often exhibit high levels of CD206, contributing to tumor progression by promoting immunosuppression, metastasis, and angiogenesis. This makes CD206 a potential target for cancer immunotherapy, as its activation can enhance both adaptive and innate antitumor immune responses.
Flow cytometric analysis of Human CD206 expression on GM-CSF and IL-4 stimulated monocytes. Human peripheral blood mononuclear cells were cultured for 3 days with 2 μg/ml Recombinant Human GM-CSF and 50 ng/ml Recombinant Human IL-4, then stained with FITC Mouse IgG1, κ Isotype Control (Left panel) or with SDT FITC Mouse Anti-Human CD206 Antibody (Right panel) at 0.25 μg/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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