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FITC Rat Anti-Mouse CD105 Antibody (S-R529)

FITC Rat Anti-Mouse CD105 Antibody (S-R529)

货号: S0B1806
价格: 650
规格: 20T
介绍: -
其他: -
产品规格
  • 宿主来源

    Rat
  • 抗原名称

    Mouse CD105
  • 分子别名

    Endoglin; Cell surface MJ7/18 antigen; Eng; Edg
  • 细胞定位

    Cell membrane
  • Accession

    Q63961
  • 克隆号

    S-R529
  • 抗体类型

    Rat mAb
  • 抗体同种型

    IgG2a,k
  • 应用

    FCM
  • 反应种属 ?

    Ms
  • 阳性样本

    bEnd.3
  • 纯化方式

    Protein G
  • 浓度

    0.2 mg/ml
  • 标记

    FITC
  • 性状

    Liquid
  • 缓冲体系

    PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300
  • 储存条件

    12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
稀释度
应用 稀释度 推荐种属
FCM 5 μl per million cells in 100μl volume Ms
背景介绍
  • Endoglin (ENG) is a type I membrane glycoprotein located on cell surfaces and is part of the TGF beta receptor complex. It is also commonly referred to as CD105, END, FLJ41744, HHT1, ORW and ORW1. Endoglin has been found to be an auxiliary receptor for the TGF-beta receptor complex. It thus is involved in modulating a response to the binding of TGF-beta1, TGF-beta3, activin-A, BMP-2, BMP-7 and BMP-9. Beside TGF-beta signaling endoglin may have other functions. It has been postulated that endoglin is involved in the cytoskeletal organization affecting cell morphology and migration. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development. In humans endoglin may be involved in the autosomal dominant disorder known as hereditary hemorrhagic telangiectasia (HHT) type 1.

  • 流式分析

    • Flow cytometric analysis of Mouse CD105 expression on bEnd.3 cells. Cells from the bEnd.3 (Mouse brain endothelioma, Right) or NIH/3T3 (Mouse embryonic fibroblast, Left) was stained with FITC Rat IgG2a, κ Isotype Control (Black line histogram) and SDT FITC Rat Anti-Mouse CD105 Antibody (Red line histogram) at 1 μg/test, cells without incubation with primary antibody and secondary antibody (Blue line histogram) was used as unlabelled control. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.