Rig-I/DDX58 Recombinant Rabbit mAb (S-1419-78)

RIG-I (Retinoic Acid-Inducible Gene I) is a cytoplasmic RNA helicase that serves as a pattern recognition receptor in innate immunity. RIG-I can recognize pathogen-associated molecular patterns (PAMPs), particularly non-self viral RNA, activating the RIG-I signaling pathway to promote cytokine production and exert antiviral effects. RIG-I primarily detects double-stranded 5'-triphosphate RNA (3pRNA) during viral or bacterial infections. Once bound to ligands in myeloid cells, RIG-I recruits an adaptor protein called mitochondrial antiviral signaling protein (MAVS) to induce the production of pro-inflammatory cytokines and type I interferons (IFN-I), as well as ASC-dependent inflammasome activation, leading to a variety of innate and adaptive immune responses. RIG-I activation is crucial for the efficacy of immune checkpoint blockade in anti-tumor therapy. Activation of the RIG-I pathway in myeloid cells can induce IFN-I-dependent natural killer cell activation and regression of metastases derived from primary melanoma.