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NA/LE Syrian Hamster anti-Mouse CD28 Recombinant mAb

NA/LE Syrian Hamster anti-Mouse CD28 Recombinant mAb

货号: S0B1142
价格: 1200
规格: 1mg
介绍: -
其他: -
产品规格
  • 宿主来源

    Syrian Hamster
  • 抗原名称

    CD28
  • 分子别名

    T-cell-specific surface glycoprotein CD28
  • 细胞定位

    Cell membrane
  • Accession

    P31041
  • 克隆号

    S-R515
  • 抗体类型

    Recombinant mAb
  • 抗体同种型

    Syrian Hamster IgG2
  • 应用

    in vitro T cell stimulation/activation, in vivo CD28 blockade, in vitro T cell stimulation/activation
  • 反应种属 ?

    Ms
  • 纯化方式

    Protein G
  • 浓度

    5 mg/ml
  • 标记

    Unconjugated
  • 性状

    Liquid
  • 缓冲体系

    PBS pH7.4, containing no preservative
  • 储存条件

    2 to 8 °C for 2 weeks under sterile conditions;

    -20 °C for 3 months under sterile conditions; 

    -80 °C for 24 months under sterile conditions.

    Please avoid repeated freeze-thaw cycles.

  • 稀释度

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背景介绍
  • CD28 is a critical costimulatory receptor expressed on the surface of T cells, particularly on CD4+ and CD8+ T cells, and plays a pivotal role in T cell activation, proliferation, and survival. It is a homodimer of 44kDa subunits, each containing a single immunoglobulin-like extracellular domain, and is part of the Ig superfamily. CD28 interacts with its ligands, CD80 (B7-1) and CD86 (B7-2), which are predominantly found on antigen-presenting cells (APCs) such as dendritic cells, macrophages, and B cells. The engagement of CD28 with these ligands is essential for providing the second signal required for full T cell activation, which complements the antigen-specific signal delivered by the T cell receptor (TCR). CD28 signaling leads to the upregulation of IL-2 and its receptor expression, enhances T cell proliferation, and promotes the production of various cytokines, including IL-4, IL-5, IL-13, IFN-γ, and TNF. It also plays a role in the differentiation of T cells into memory phenotypes and in maintaining immune homeostasis. The absence of CD28 signaling results in reduced T cell survival and impaired antibody responses to T-dependent antigens. CD28 is thus a key regulatory point for successful B cell, macrophage, and cytotoxic T cell responses.