PBS, 1% BSA, 0.3% Proclin 300
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| FCM | 5 μl per million cells in 100μl volume | Hu |
CD45RO is an important cell surface marker in immunology that belongs to the CD45 family (also known as Leukocyte Common Antigen, LCA). CD45 is a highly polymorphic transmembrane protein primarily expressed on the surface of white blood cells, including T cells, B cells, natural killer (NK) cells, monocytes, and granulocytes, and plays a crucial role in lymphocyte development, activation, and signaling. Specifically, CD45RO is an isoform of CD45 that is highly expressed on memory T cells but expressed at lower levels or not expressed on naive T cells. Memory T cells are T cells that have been activated and survived during previous immune responses, enabling them to rapidly and strongly activate upon re-encountering the same antigen, thus accelerating and enhancing immune responses. Therefore, CD45RO is often used to distinguish and identify memory T cells. It serves as an important marker in immune phenotyping analysis, disease diagnosis, immune response monitoring, and immunotherapy research.
Multiparameter flow cytometric analysis of Human CD45RO expression on human peripheral blood mononuclear cell populations. Human peripheral blood mononuclear cells were stained with PE-Cy5.5 Mouse Anti-Human CD45RA antibody and either PE-Cy7 Mouse IgG2a, κ Isotype Control (Left panel) or SDT PE-Cy7 Mouse Anti-Human CD45RO antibody (Right panel) at 0.1 μg/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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