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Mouse Anti-Human CD41a Antibody (S-R554)

Mouse Anti-Human CD41a Antibody (S-R554)

货号: S0B1120
价格: 600
规格: 25μl
介绍: -
其他: -
产品规格
  • 宿主来源

    Mouse
  • 抗原名称

    CD41a
  • 分子别名

    Integrin alpha-IIb; GPalpha IIb (GPIIb); Platelet membrane glycoprotein IIb; ITGA2B; GP2B; ITGAB
  • 细胞定位

    Membrane
  • Accession

    P08514
  • 克隆号

    S-R554
  • 抗体类型

    Mouse mAb
  • 抗体同种型

    IgG1
  • 应用

    FCM
  • 反应种属 ?

    Hu
  • 阳性样本

    human peripheral blood
  • 纯化方式

    Protein G
  • 浓度

    2 mg/ml
  • 标记

    Unconjugated
  • 性状

    Liquid
  • 缓冲体系

    PBS pH7.4
  • 储存条件

    12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

稀释度
应用 稀释度 推荐种属
FCM 1:2000 Hu
背景介绍
  • CD41, also known as Integrin α-IIb or GPαIIb, is a protein expressed on platelets and megakaryocytes. CD41 is a component of the platelet membrane glycoprotein complex and non-covalently associates with CD61 (Integrin β-3) to form the αIIbβ3 complex, which is an essential integrin in platelets. It plays a crucial role in platelet activation and aggregation, particularly during thrombus formation and hemostasis. In clinical practice, the detection of CD41 is essential for diagnosing and studying platelet-related diseases. For instance, immunostaining for CD41 can help identify micromegakaryocytes, which might be confused with primitive megakaryocytes or lymphocytes in Wright-Giemsa staining, leading to missed diagnoses. CD41 staining can significantly improve the detection rate of micromegakaryocytes, which is crucial for the diagnosis and therapeutic monitoring of certain hematological disorders.

  • 流式分析

    • Flow cytometric analysis of human peripheral blood labelling Human CD41a antibody at 1/2000 (0.1 μg) dilution (Right) compared with a Mouse monoclonal IgG isotype control (Left). Goat Anti - Mouse IgG Alexa Fluor® 647 was used as the secondary antibody. Then cells were stained with CD42b - Alexa Fluor® 488 separately. Gated on total viable cells.