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Alexa Fluor® 488 Mouse Anti-Human CD16a Antibody (S-564-39)

Alexa Fluor® 488 Mouse Anti-Human CD16a Antibody (S-564-39)

货号: S0B1659
价格: 650
规格: 20T
介绍: -
其他: -
产品规格

  • 宿主来源

    Mouse

  • 抗原名称

    CD16a

  • 分子别名

    Low affinity immunoglobulin gamma Fc region receptor III-A; IgG Fc receptor III-A; CD16-II; CD16a antigen; Fc-gamma RIII-alpha; Fc-gamma RIII; FcRIII; FcRIIIa; FcgammaRIIIA; FcR-10; IgG Fc receptor III-2; FCGR3A; FCG3; FCGR3; IGFR3

  • 免疫原

    Synthetic Peptide

  • 细胞定位

    Secreted, Cell membrane

  • Accession

    P08637

  • 克隆号

    S-564-39

  • 抗体类型

    Mouse mAb

  • 抗体同种型

    IgG1,k

  • 应用

    FCM

  • 反应种属 ?

    Hu

  • 阳性样本

    Human PBMC

  • 纯化方式

    Protein G

  • 浓度

    50μg/ml

  • 标记

    Alexa Fluor® 488

  • 性状

    Liquid

  • 缓冲体系

    PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300

  • 储存条件

    12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
稀释度
应用 稀释度 推荐种属
FCM 5 μl per million cells in 100μl volume Hu
背景介绍

  • CD16 has been identified as Fc receptors FcγRIIIa (CD16a) and FcγRIIIb (CD16b), which participate in signal transduction. The most well-researched membrane receptor implicated in triggering lysis by NK cells, CD16 is a molecule of the immunoglobulin superfamily (IgSF) involved in antibody-dependent cellular cytotoxicity (ADCC). It can be used to isolate populations of specific immune cells through fluorescent-activated cell sorting (FACS) or magnetic-activated cell sorting, using antibodies directed towards CD16. CD16 plays a significant role in early activation of natural killer (NK) cells following vaccination. In addition, CD16 downregulation represents a possible way to moderate NK cell responses and maintain immune homeostasis in both T cell and antibody-dependent signaling pathways.