PBS pH7.4, containing no preservative
2 to 8 °C for 2 weeks under sterile conditions;
-20 °C for 3 months under sterile conditions;
-80 °C for 24 months under sterile conditions.
Please avoid repeated freeze-thaw cycles.
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| WB | 1:1000 | Ms |
Tumor Necrosis Factor-alpha (TNF-α) is a homotrimeric protein consisting of 157 amino acids and serves as a potent pro-inflammatory cytokine. It plays a crucial role in various biological functions, including immune responses, inflammatory processes, cell growth, and apoptosis, by binding to its receptors TNFR1 and TNFR2. The dysregulation of TNF-α is associated with a multitude of diseases, such as autoimmune diseases, insulin resistance, psoriasis, rheumatoid arthritis, ankylosing spondylitis, tuberculosis, autosomal dominant polycystic kidney disease, and cancer. In the treatment of autoimmune diseases, TNF-α inhibitors have become an essential therapeutic strategy, with examples including infliximab, etanercept, and adalimumab. In the context of in vitro diagnostic (IVD) applications, TNF-α is often measured in the blood to assess inflammatory responses across a broad spectrum of diseases.
WB result of Invivo anti-mouse TNFα Recombinant mAb
Primary antibody: Invivo anti-mouse TNFα Recombinant mAb at 1/1000 dilution
Lane 1: TNF-α Protein, Human 10 µg
Lane 2: TNF-α Protein, Mouse 10 µg
Secondary antibody: Goat Anti-rat IgG, (H+L), HRP conjugated at 1/10000 dilution
Predicted MW: 26 kDa
Observed MW: 17 kDa
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