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Alexa Fluor® 488 Mouse Anti-Human CD33 Antibody (S-R472)

Alexa Fluor® 488 Mouse Anti-Human CD33 Antibody (S-R472)

货号: S0B1604
价格: 1790
规格: 100T
介绍: -
其他: -
产品规格
  • 宿主来源

    Mouse
  • 抗原名称

    CD33
  • 分子别名

    PWS44, Myeloid cell surface antigen CD33, Sialic acid-binding Ig-like lectin 3, Siglec-3, gp67
  • 细胞定位

    Membrane
  • Accession

    P20138
  • 克隆号

    S-R472
  • 抗体类型

    Mouse mAb
  • 抗体同种型

    IgG2a,k
  • 应用

    FCM
  • 反应种属 ?

    Hu
  • 纯化方式

    Protein A
  • 浓度

    0.1mg/ml
  • 标记

    Alexa Fluor® 488
  • 性状

    Liquid
  • 缓冲体系

    PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300

  • 储存条件

    12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

稀释度
应用 稀释度
FCM 5 μl per million cells in 100μl volume
背景介绍
  • CD33 or Siglec-3 (sialic acid binding Ig-like lectin 3, SIGLEC3, SIGLEC-3, gp67, p67) is a transmembrane receptor expressed on cells of myeloid lineage. It is usually considered myeloid-specific, but it can also be found on some lymphoid cells. CD33 can be stimulated by any molecule with sialic acid residues such as glycoproteins or glycolipids. Upon binding, the immunoreceptor tyrosine-based inhibition motif (ITIM) of CD33, present on the cytosolic portion of the protein, is phosphorylated and acts as a docking site for Src homology 2 (SH2) domain-containing proteins like SHP phosphatases. This results in a cascade that inhibits phagocytosis in the cell.