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Lamin B1 Recombinant Rabbit mAb (HRP Conjugate) (SDT-307-108)

Lamin B1 Recombinant Rabbit mAb (HRP Conjugate) (SDT-307-108)

货号: S0B1595
价格: 720
规格: 25μl
介绍: -
其他: -
产品规格

  • 宿主来源

    Rabbit

  • 抗原名称

    Lamin B1

  • 分子别名

    Lamin-B1, LMN2, LMNB, LMNB1

  • 免疫原

    Synthetic Peptide

  • 细胞定位

    Nucleus lamina

  • Accession

    P20700

  • 克隆号

    SDT-307-108

  • 抗体类型

    Recombinant mAb

  • 抗体同种型

    IgG

  • 应用

    WB

  • 反应种属 ?

    Hu, Ms, Rt

  • 纯化方式

    Protein A

  • 浓度

    2 mg/ml

  • 标记

    HRP

  • 性状

    Liquid

  • 缓冲体系

    PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

  • 储存条件

    12 months from date of receipt / reconstitution, -20 °C as supplied

稀释度
应用 稀释度
WB 1:5000-1:50000
背景介绍

  • Lamin B1 is a critical component of the nuclear lamina, a protein network underlying the inner nuclear membrane, and plays essential roles in nuclear organization, chromatin regulation, and cell proliferation. It is particularly important during brain development, where it contributes to neuronal migration and the maintenance of nuclear integrity. Lamin B1 also interacts with chromatin and the nuclear pore complex, influencing gene expression and DNA replication. The balance of Lamin B1 is crucial; both its overexpression and deficiency can lead to developmental abnormalities and neurodegenerative diseases. Recent studies have highlighted its dynamic association with euchromatin regions, suggesting a role in gene regulation and the cellular response to stimuli such as epithelial-to-mesenchymal transition (EMT). Lamin B1's interaction with the genome is complex and involves the formation of lamina-associated domains (LADs), which can change during cellular transformations, indicating its active participation in chromatin remodeling and the regulation of cellular identity.

  • 免疫印迹

    • WB result of Lamin B1 Recombinant Rabbit mAb (HRP Conjugate)
      Lysate: HeLa whole cell lysate 20 µg
      Lane 1: Lamin B1 Recombinant Rabbit mAb (HRP Conjugate) at 1/5000 dilution
      Lane 2: Lamin B1 Recombinant Rabbit mAb (HRP Conjugate) at 1/10000 dilution
      Lane 3: Lamin B1 Recombinant Rabbit mAb (HRP Conjugate) at 1/50000 dilution
      Lane 4: Lamin B1 Recombinant Rabbit mAb (HRP Conjugate) at 1/100000 dilution
      Predicted MW: 68 kDa
      Observed MW: 68 kDa

    • WB result of Lamin B1 Recombinant Rabbit mAb (HRP Conjugate)
      Lysate: mouse spleen lysate 20 µg
      Lane 1: Lamin B1 Recombinant Rabbit mAb (HRP Conjugate) at 1/5000 dilution
      Lane 2: Lamin B1 Recombinant Rabbit mAb (HRP Conjugate) at 1/10000 dilution
      Lane 3: Lamin B1 Recombinant Rabbit mAb (HRP Conjugate) at 1/50000 dilution
      Lane 4: Lamin B1 Recombinant Rabbit mAb (HRP Conjugate) at 1/100000 dilution
      Predicted MW: 68 kDa
      Observed MW: 68 kDa

    • WB result of Lamin B1 Recombinant Rabbit mAb (HRP Conjugate)
      Lysate: rat heart lysate 10 µg
      Lane 1: Lamin B1 Recombinant Rabbit mAb (HRP Conjugate) at 1/5000 dilution
      Lane 2: Lamin B1 Recombinant Rabbit mAb (HRP Conjugate) at 1/10000 dilution
      Lane 3: Lamin B1 Recombinant Rabbit mAb (HRP Conjugate) at 1/50000 dilution
      Lane 4: Lamin B1 Recombinant Rabbit mAb (HRP Conjugate) at 1/100000 dilution
      Predicted MW: 68 kDa
      Observed MW: 68 kDa