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TMEM119 Fc Chimera Protein, Human

货号: UA010710

价格: 3620

规格: 100μg

介绍: -

其他: -

产品规格

物种

Human
分子别名

TMEM119,OBIF
Accession

Q4V9L6
表达序列

Arg26-Met96, with C-hIgG1 Fc
表达宿主

HEK293
分子量

37-50kDa (Reducing)
纯度

＞95% by SDS-PAGE
内毒素含量

<0.1EU/μg
标记

Unconjugated
标签

Human Fc Tag
性状

Lyophilized Powder
缓冲体系

PBS, pH7.4.
溶解方法

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
文献引用

1.Jiang, Z,H. et al. (2017) Expt & Mol Med. 49:e329. 2.Satoh, J. et al. (2016) Neuropathol. 36:39.

背景介绍

TMEM119 (Transmembrane Protein 119, also known as Osteoblast Induction Factor or OBIF), is an approximately 38-kDa type 1 transmembrane protein. Mature human TMEM119 consists of a 71 amino acid (aa) extracellular domain (ECD), a 21 aa transmembrane segment, and a 166 aa cytoplasmic domain. It is predominantly expressed in osteoblasts and is upregulated during osteoblastic differentiation. TMEM-119 is involved in the osteoblast differentiation and bone development by acting as a ligand and has been reported to contribute to the proliferation, migration, and invasion of osteosarcoma cells, as well as functioning as an oncogene in osteosarcoma.