Wenjing Song, Xin He, Pengju Gong, Yan Yang, Sirui Huang, Yifan Zeng, Jingwei Zhang. IGFLR1 as a Novel Prognostic Biomarker in Clear Cell Renal Cell Cancer Correlating With Immune Infiltrates. Front Mol Biosci. 2020 Nov 26;7:565173.eCollection 2020.
Insulin Growth Factor-Like receptor 1 (IGFLR1), also known as transmembrane protein 149 (TMEM149), is a protein encoding gene located on chromosome 19 and is widely expressed in lymph nodes, spleen and kidney. Although studies have shown that high expression level of IGFLR1 could predict poor survival among patients with ccRCC (Clear cell renal cell carcinoma), the mechanism of the cancer-promoting effect of IGFLR1 has been still unclear and previous studies were limited to carbohydrate metabolism. Adrian et al. found that IGFLR1 was similar in structure to the tumor necrosis factor receptor family (TNFRs) and considered to be a novel receptor in the TNFRs. IGFLR1 may be a tumor immune-related molecule. However, the potential function and prognostic value of IGFLR1 in tumor progression and tumor immunology remained unclear.
1μg (R: reducing condition, N: non-reducing condition).
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