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Biotinylated CEACAM-6/CD66c Fc&Avi Tag Protein, Human

货号: UA010740

价格: 2800

规格: 25μg

介绍: -

其他: -

产品规格

物种

Human
分子别名

NCA
Accession

P40199-1
表达序列

Lys35-Gly320, with C-hIgG1 Fc and Avi tag
表达宿主

HEK293
分子量

72-95kDa (Reducing)
纯度

＞95% by SDS-PAGE
内毒素含量

<0.1EU/μg
标记

Biotin
标签

Human Fc Tag, Avi Tag
性状

Lyophilized Powder
缓冲体系

PBS, pH7.4.
溶解方法

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
文献引用

1. Laura A Strickland,Preclinical evaluation of carcinoembryonic cell adhesion molecule (CEACAM) 6 as potential therapy target for pancreatic adenocarcinoma,Journal of Pathology,J Pathol 2009; 218: 380–39.

背景介绍

CEACAM6 is a glycosylphosphoinosi-tol (GPI)-linked, cell surface protein and a member of the CEA family of proteins. Structurally, this protein has two C2-type Ig domains and a single N-terminal V-type Ig domain and shares close homology with CEACAM1, CEACAM7 and CEACAM8. Function-ally, CEACAM6 has been implicated in cell adhesion, cellular invasiveness, resistance to anoikis and metastatic behaviour of tumour cells, which are properties investigators have previously tried to exploit using various CEACAM6-targeted therapy approaches.