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Eotaxin/CCL11 Protein, Human

货号: UA040163

价格: 680

规格: 10μg

介绍: -

其他: -

产品规格

物种

Human
分子别名

C-C motif chemokine 11, Eosinophil chemotactic protein, Small-inducible cytokine A11
Accession

P51671
表达序列

Gly24-Pro97
表达宿主

E.coli
分子量

10kDa (Reducing)
纯度

＞95% by SDS-PAGE
内毒素含量

<0.1EU/μg
标记

Unconjugated
标签

No Tag
性状

Lyophilized Powder
缓冲体系

PBS, pH7.4.
溶解方法

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
文献引用

Acta Neurol Belg. 2022; 122(4): 865–869. Pharmaceuticals (Basel). 2020 Sep; 13(9): 230.

背景介绍

Eotaxin/CCL11, produced by eosinophils, B-cells, fibroblasts, endothelial cells, macrophages, chondrocytes and other cells, is a member of the eotaxin family that is chemotactic agents for eosinophils and participate in innate immunity. It is induced by T helper-2 cytokines, like IL-13, IL-10 and IL-4, then transported from the blood to the brain through the Blood-Brain Barrier (BBB). Eotaxin/CCL11 may exert physiological and pathological functions in the central nerve system, and may induce neuronal cytotoxicity effects by inducing the production of reactive oxygen species (ROS) in microglia cells. Plasma levels of CCL11 elevated in neuroinflammation and neurodegenerative disorders.