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SCARB2/SR-B2/LIMPII Fc Chimera Protein, Mouse

货号: UA010804

价格: 2079

规格: 100μg

介绍: -

其他: -

产品规格

物种

Mouse
分子别名

SR-B2, SCARB2, CD36L2, LIMP2, LIMPII
Accession

O35114
表达序列

Arg27-Thr432, with C-terminal hIgG1 Fc
表达宿主

HEK293
分子量

82-95kDa (Reducing)
纯度

＞95% by SDS-PAGE
内毒素含量

<0.1EU/μg
标记

Unconjugated
标签

Human Fc Tag
性状

Lyophilized Powder
缓冲体系

PBS, pH7.4.
溶解方法

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
文献引用

Neculai D. et al. (2013) Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36. Nature. 504: 172-176.

背景介绍

LIMPII (Lysosomal Integral Membrane Protein II), also known as LPG85 (85 kDa lysosomal membrane sialoglycoprotein) and as CD36 antigen-like 2 (CD36L2), is a major lysosomal membrane protein. LIMP-II is a type-III protein that traverses the membrane twice, with an N-terminal transmembrane anchor as a result of an uncleaved signal peptide and a second membrane spanning region near the C-terminus, followed by a 20 amino acid cytoplasmic tail. LIMPII is currently known to be a member of a superfamily of scavenger receptor proteins (class B), which also includes scavenger receptor (SR)-B1 and SR-B3. These three proteins share their structure, which comprises two transmembrane domains, a relatively large extracellular domain, and both the amino and carboxyl termini located within the cytoplasm. LIMPII as the mannose-6-phosphate- independent trafficking receptor for beta-glucocerebrosidase.