Gln26-Lys482, with C-terminal His
90-130kDa (Reducing)
PBS, pH7.4.
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
1.Anderson, J.N. et al. (2004) FASEB J. 18:8. 2.Streuli, M. et al. (1987) J. Exp. Med. 166:1548. 3.Hermiston, M.L. et al. (2003) Annu. Rev. Immunol. 21:107.
Protein tyrosine phosphatase, receptor type C (CD45), also known as PTPRC is a member of the protein tyrosine phosphatase (PTP) family which is known for its function to serve as signaling molecules and to regulate a variety of cellular processes such as cell proliferation, differentiation, mitotic cycle and oncogenic transformation. It is a variably glycosylated 180-220 kDa transmembrane protein that is abundantly expressed on all nucleated cells of hematopoietic origin.Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity.
2μg (R: reducing condition, N: non-reducing condition).
Immobilized CD45RA His Tag, Human (Cat. No. UA010812) at 2.0μg/mL (100μL/well) can bind CD45RA Recombinant Mouse mAb (S-R377) (Cat. No. S0B0626) with EC50 of 0.73-1.46ng/ml.
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