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MARCO(405-520) His Tag Protein, Human

货号: UA010816

价格: 3080

规格: 100μg

介绍: -

其他: -

产品规格

物种

Human
分子别名

MARCO, SCARA2, Macrophage receptor with collagenous structure, Scavenger receptor class A member 2
Accession

Q9UEW3
表达序列

Ser405-Val520, with C-terminal His
表达宿主

HEK293
分子量

14-17kDa (Reducing)
纯度

＞95% by SDS-PAGE
内毒素含量

<0.1EU/μg
标记

Unconjugated
标签

His Tag
性状

Lyophilized Powder
缓冲体系

50mM Tris,0.1M NaCl,0.3M Arg, pH8.0.
溶解方法

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
文献引用

1.Sheetal, A. et al. (2008) J. Immunotoxicol. 5:151.

背景介绍

MARCO (macrophage receptor with collagenous structure), also known as SCARA2, is an 80 kDa type II transmembrane glycoprotein that belongs to the class A scavenger receptor family. MARCO is constitutively expressed on the surface of splenic and lymph node macrophages. Its expression is induced on Kupffer cells and alveolar macrophages by microbial infection, chemical irritants, and Th1 polarizing factors. MARCO binds LPS, lipoteichoic acid, and other determinants on Gram positive and negative bacteria. It also binds modified LDL, CpG oligonucleotides, UGRP1, silica, and TiO2. MARCO is required for the organization of the splenic marginal zone and the interaction of local macrophages and B cells.