PBS pH7.4
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| FCM | 1:200 | Hu |
CD244, also known as 2B4 or SLAMF4, is a type-I transmembrane protein belonging to the signaling lymphocytic activation molecule (SLAM) family. It is expressed on various immune cells, including NK cells, T cells, monocytes, eosinophils, myeloid-derived suppressor cells, and dendritic cells. CD244 primarily binds to CD48, another member of the SLAM family, to regulate immune responses through both stimulatory and inhibitory signals. Its cytoplasmic domain contains four immunoreceptor tyrosine-based switch motifs (ITSMs) that interact with proteins like SAP, EAT2, and phosphatases to transmit signals. CD244 plays a significant role in immune regulation and has potential as a therapeutic target in diseases such as cancer and autoimmune disorders.
Flow cytometric analysis of Human Peripheral Blood labelling Human CD244 antibody at 1/200 (1 μg) dilution/ (Right panel) compared with a Mouse IgG2a, κ Isotype Control / (left panel). Goat Anti-Mouse IgG Alexa Fluor® 647 was used as the secondary antibody. Then cells were stained with CD56 - PE antibody separately.
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