Protein sequence (P25116, Ser42-Thr102, with C-His tag) SFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLT
Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose.
12 months from date of receipt, -20 to -70 °C as supplied.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
1 week, 2 to 8 °C under sterile conditions after reconstitution.
Please avoid repeated freeze-thaw cycles.
Protease-activated receptor 1 (PAR1), also known as thrombin receptor, is a member of the G-protein-coupled receptor (GPCR) family and a critical mediator of cellular responses to proteolytic enzymes, particularly thrombin. Activated by proteolytic cleavage at its N-terminal domain, PAR1 initiates signaling cascades via G proteins (e.g., Gαq/11, Gα12/13), regulating processes like platelet aggregation, vascular smooth muscle contraction, inflammation, and wound healing. Dysregulated PAR1 signaling is implicated in thrombosis, atherosclerosis, cancer cell migration, and fibrotic diseases.
2μg（R: reducing conditions）
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