PBS, 1% BSA, 0.3% Proclin 300
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| FCM | 1.25μl per million cells in 100μl volume | Hu |
CD11b, also known as integrin alpha M (ITGAM), is a cell surface receptor belonging to the integrin family and primarily expressed on immune cells such as macrophages, monocytes, neutrophils, and NK cells. It forms a heterodimer with CD18 to create the β2 integrin complex, which is crucial for mediating cell adhesion, migration, and immune responses. CD11b plays a significant role in leukocyte recruitment and activation during inflammation and immune responses by interacting with ligands like ICAM-1 and iC3b. Additionally, it is involved in phagocytosis and immune regulation in various diseases, including cancer and autoimmune conditions.
Flow cytometric analysis of Human CD11b expression on human PBMC (human peripheral blood mononuclear cell). Human PBMC were stained with Brilliant Violet 510™ Mouse Anti-Human CD14 antibody and either APC Rat IgG2b, κ Isotype Control (Left panel) or SDT APC Rat Anti- Human CD11b antibody (Right panel) at 5 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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