PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300
12 months from date of receipt / reconstitution, -20 °C as supplied
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| FCM | 5μl per million cells in 100μl volume | Hu |
CD4 is a glycoprotein found on the surface of certain immune cells, such as helper T cells, monocytes, macrophages, and dendritic cells. It is a monomeric type I transmembrane molecule composed of four immunoglobulin-like domains (D1 to D4) and encoded by a single gene. As a co-receptor for the T-cell receptor (TCR), CD4 plays a crucial role in the immune response by binding to the MHC class II molecules on antigen-presenting cells, which helps T cells recognize and respond to foreign antigens. The interaction between CD4 and MHC class II molecules also activates downstream signaling pathways, leading to the activation of transcription factors and promoting T cell activation. Additionally, CD4 is significant in HIV infection, as the virus binds to CD4 to enter host cells.
Flow cytometric analysis of Human CD4 expression on human peripheral blood lymphocytes. Human peripheral blood lymphocytes were stained with Alexa Fluor® 647 Mouse Anti-Human CD3 antibody and either Pacific Blue™ Rabbit IgG Isotype Control (Left panel) or SDT Pacific Blue™ Rabbit Anti-Human CD4 Antibody (Right panel) at 5 μl/test. Fluorescent histograms were gated events with lymphocytes. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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