PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
12 months from date of receipt / reconstitution, -20°C as supplied
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| WB | 1:1000 | Hu |
| IHC-P | 1:250 | Hu |
PSEN2, which stands for presenilin 2, is a protein encoded by the PSEN2 gene. It is an integral membrane protein that is a key component of the gamma-secretase enzyme complex. This complex is involved in the cleavage of amyloid precursor protein (APP), which generates amyloid-beta peptides. Mutations in the PSEN2 gene have been linked to early-onset familial Alzheimer's disease, as these mutations can lead to an increased production of amyloid-beta 42, a peptide that is more prone to aggregate and form plaques in the brain. PSEN2 is primarily located in the endoplasmic reticulum and Golgi apparatus, and it plays a crucial role in regulating cellular processes such as protein trafficking and signal transduction.
WB result of PSEN2 Recombinant Rabbit mAb
Primary antibody: PSEN2 Recombinant Rabbit mAb at 1/1000 dilution
Lane 1: SH-SY5Y whole cell lysate 20 µg
Lane 2: HeLa whole cell lysate 20 µg
Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
Predicted MW: 50 kDa
Observed MW: 21 kDa
IHC shows positive staining in paraffin-embedded human cerebral cortex. Anti-PSEN2 antibody was used at 1/250 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human endometrial cancer. Anti-PSEN2 antibody was used at 1/250 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human lung adenocarcinoma. Anti-PSEN2 antibody was used at 1/250 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
Expression of PSEN2 in tumor tissue.
Expression of PSEN2 in human tissue.
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