PBS, 0.2% BSA, 0.1% Proclin 300
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| FCM | 1.25μl per million cells in 100μl volume | Ms |
CD335, also known as NKp46 or Natural Cytotoxicity Triggering Receptor 1 (NCR1), is a 46 kDa type I transmembrane glycoprotein that belongs to the natural cytotoxicity receptor family. It is primarily expressed on natural killer (NK) cells and plays a crucial role in their activation and cytotoxicity. CD335 can recognize and bind to viral hemagglutinins and heparan sulfate proteoglycans on target cells, triggering NK cell-mediated cytotoxic responses. This receptor is involved in non-MHC-restricted natural cytotoxicity and is essential for the immune system's ability to detect and eliminate infected or transformed cells.
Flow cytometric analysis of Mouse CD335 expression on C57BL/6 mouse splenocytes. C57BL/6 mouse splenocytes were stained with FITC Rat Anti-Mouse NK1.1 antibody and either FITC Rat IgG2a, κ Isotype Control (Left panel) or SDT APC Rat Anti-Mouse CD335 Antibody (Right panel) at 1.25 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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