PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
12 months from date of receipt / reconstitution, -20 °C as supplied
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| WB | 1:1000 | Hu, Ms, Rt |
The NMDA Receptor 1 (GluN1) protein is an essential subunit of NMDA receptors, which are ligand-gated ion channels that play crucial roles in excitatory neurotransmission, synaptic plasticity, learning, and memory in the central nervous system. GluN1 is required for the formation and function of all NMDA receptor complexes, as it binds glycine or D-serine and provides structural support for the receptor. This subunit is widely expressed in neurons and undergoes alternative splicing to produce multiple isoforms, each with distinct functional and pharmacological properties. For example, the presence of exon 5 in GluN1 reduces agonist potency and accelerates receptor deactivation. Additionally, GluN1's intracellular carboxyl-terminal domain interacts with various proteins involved in receptor trafficking and anchoring at synapses. Abnormal activity of GluN1-containing receptors has been implicated in several neurological and psychiatric disorders, making it a target for therapeutic interventions.
WB result of NMDA Receptor 1 (GluN1) Recombinant Rabbit mAb
Primary antibody: NMDA Receptor 1 (GluN1) Recombinant Rabbit mAb at 1/1000 dilution
Lane 1: unboiled mouse brain lysate 20 µg
Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
Predicted MW: 105 kDa
Observed MW: 120 kDa
WB result of NMDA Receptor 1 (GluN1) Recombinant Rabbit mAb
Primary antibody: NMDA Receptor 1 (GluN1) Recombinant Rabbit mAb at 1/1000 dilution
Lane 1: unboiled rat brain lysate 20 µg
Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
Predicted MW: 105 kDa
Observed MW: 120 kDa
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