PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
12 months from date of receipt / reconstitution, -20 °C as supplied
应用 | 稀释度 | 推荐种属 |
---|---|---|
WB | 1:1000 | Hu |
The cellular prion protein (PrPC) is a glycosylphosphatidylinositol (GPI)-anchored glycoprotein encoded by the PRNP gene and predominantly expressed in neurons, although it is also found in other tissues such as lymphoid organs and the heart. PrPC has a flexible N-terminal tail and a structured C-terminal core, allowing it to interact with a wide range of partners. Its proposed physiological functions include ion balance homeostasis, neuritogenesis, neuronal protection against oxidative stress, and modulation of cell signaling pathways. However, only its role in peripheral nerve myelination homeostasis has been definitively confirmed. Misfolding of PrPC into the pathogenic PrPSc isoform leads to prion diseases, which are characterized by neurodegeneration.
WB result of PrPC Recombinant Rabbit mAb
Primary antibody: PrPC Recombinant Rabbit mAb at 1/1000 dilution
Lane 1: MCF7 whole cell lysate 20 µg
Lane 2: SK-MEL-28 whole cell lysate 20 µg
Negative control: MCF7 whole cell lysate
Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
Predicted MW: 28 kDa
Observed MW: 20-37 kDa