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PrPC Recombinant Rabbit mAb (S-2053-29)

PrPC Recombinant Rabbit mAb (S-2053-29)

货号: S0B6041
价格: 600
规格: 25μl
介绍: -
其他: -
产品规格
  • 宿主来源

    Rabbit
  • 抗原名称

    PrPC
  • 分子别名

    Major prion protein; PrP; ASCR; PrP27-30; PrP33-35C; CD230; ALTPRP; PRIP; PRNP
  • 免疫原

    Synthetic Peptide
  • 细胞定位

    Cell membrane
  • Accession

    P04156
  • 克隆号

    S-2053-29
  • 抗体类型

    Recombinant mAb
  • 抗体同种型

    IgG
  • 应用

    WB
  • 反应种属 ?

    Hu
  • 阳性样本

    SK-MEL-28
  • 预测反应种属
    (反应种属缩写表)

    Gor, Or
  • 纯化方式

    Protein A
  • 浓度

    0.5 mg/ml
  • 标记

    Unconjugated
  • 性状

    Liquid
  • 缓冲体系

    PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

  • 储存条件

    12 months from date of receipt / reconstitution, -20 °C as supplied

稀释度
应用 稀释度 推荐种属
WB 1:1000 Hu
背景介绍
  • The cellular prion protein (PrPC) is a glycosylphosphatidylinositol (GPI)-anchored glycoprotein encoded by the PRNP gene and predominantly expressed in neurons, although it is also found in other tissues such as lymphoid organs and the heart. PrPC has a flexible N-terminal tail and a structured C-terminal core, allowing it to interact with a wide range of partners. Its proposed physiological functions include ion balance homeostasis, neuritogenesis, neuronal protection against oxidative stress, and modulation of cell signaling pathways. However, only its role in peripheral nerve myelination homeostasis has been definitively confirmed. Misfolding of PrPC into the pathogenic PrPSc isoform leads to prion diseases, which are characterized by neurodegeneration.

  • 免疫印迹

    • WB result of PrPC Recombinant Rabbit mAb
      Primary antibody: PrPC Recombinant Rabbit mAb at 1/1000 dilution
      Lane 1: MCF7 whole cell lysate 20 µg
      Lane 2: SK-MEL-28 whole cell lysate 20 µg
      Negative control: MCF7 whole cell lysate
      Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 28 kDa
      Observed MW: 20-37 kDa