PBS pH7.4
2 to 8 °C for 2 weeks under sterile conditions;
-20 °C for 3 months under sterile conditions;
-80 °C for 24 months under sterile conditions.
Please avoid repeated freeze-thaw cycles.
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| FCM | 1:5000 | Ms |
CD200 (OX2) protein is a type-1 membrane glycoprotein belonging to the immunoglobulin superfamily, widely distributed on various cell types including thymocytes, neurons, endothelial cells, and immune cells such as macrophages and dendritic cells. It plays a crucial role in immune regulation by interacting with its receptor CD200R, which is highly expressed on myeloid cells and some lymphoid cells. The CD200-CD200R interaction inhibits inflammatory responses, promotes immune tolerance, and helps maintain tissue homeostasis. In cancer, CD200 is often overexpressed on tumor cells, contributing to immune evasion by suppressing anti-tumor immune responses. Additionally, elevated levels of soluble CD200 (sCD200) in serum are associated with adverse tumor prognosis in several cancers.
Flow cytometric analysis of BALB/c mouse splenocytes labelling Mouse CD200 antibody at 1/5000 (0.1 μg) dilution/ (Right panel) compared with a Mouse IgG1, κ Isotype Control / (Left panel). Goat Anti-Rat IgG Alexa Fluor® 647 was used as the secondary antibody.
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