PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| FCM | 5μl per million cells in 100μl volume | Rt |
CD71, also known as transferrin receptor 1 (TfR1), is a type II transmembrane glycoprotein that exists as a disulfide-linked homodimer on the cell surface. It plays a crucial role in cellular iron uptake by binding to iron-bound transferrin and mediating its internalization through receptor-mediated endocytosis. CD71 is widely expressed on proliferating cells, including erythroid precursors, activated immune cells, and various cancer cells. It is also a preferred entry receptor for several viruses, such as arenaviruses and hepatitis C virus. In addition, CD71 has been identified as a marker for cell proliferation and activation, and its expression is often used in the diagnosis and prognosis of hematological diseases.
Flow cytometric analysis of Rat CD71 expression on SD Rat bone marrow. SD Rat bone marrow was stained with Alexa Fluor® 647 Mouse IgG2a, κ Isotype Control (Black line histogram) or SDT Alexa Fluor® 647 Mouse Anti-Rat CD71 Antibody (Red line histogram) at 5 μl/test, cells without incubation with primary antibody and secondary antibody (Blue line histogram) was used as unlabelled control. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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