PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
12 months from date of receipt / reconstitution, -20 °C as supplied
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| WB | 1:1000 | Hu |
AXL protein is a receptor tyrosine kinase and a member of the Tyro3-Axl-Mer (TAM) subfamily, characterized by an extracellular domain with two immunoglobulin-like motifs and two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein Gas6. This binding induces AXL dimerization and autophosphorylation, activating downstream molecules like PI3-kinase subunits, GRB2, and PLCG1, which in turn triggers AKT kinase activation. AXL is involved in various cellular functions, including cell survival, proliferation, migration, and differentiation. It also plays a role in immune modulation by inhibiting Toll-like receptor-mediated innate immune responses. Additionally, AXL serves as a host cell receptor for several viruses, such as Marburg, Ebola, Lassa, and potentially SARS-CoV-2.
WB result of AXL Rabbit pAb
Primary antibody: AXL Rabbit pAb at 1/1000 dilution
Lane 1: Jurkat whole cell lysate 20 µg
Lane 2: HeLa whole cell lysate 20 µg
Negative control: Jurkat whole cell lysate
Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
Predicted MW: 98 kDa
Observed MW: 130 kDa
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