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Pacific Blue Mouse Anti-Human CD8 Antibody(S-R533)

Pacific Blue Mouse Anti-Human CD8 Antibody(S-R533)

货号: S0B5228
价格: 250
规格: 20T
介绍: -
其他: -
产品规格
  • 宿主来源

    Mouse
  • 抗原名称

    CD8α
  • 分子别名

    T-cell surface glycoprotein CD8 alpha chain; T-lymphocyte differentiation antigen T8/Leu-2; MAL; CD8A
  • 细胞定位

    Cell membrane
  • Accession

    P01732
  • 克隆号

    S-R533
  • 抗体类型

    Mouse mAb
  • 抗体同种型

    IgG1
  • 应用

    FCM
  • 反应种属 ?

    Hu
  • 阳性样本

    human peripheral blood lymphocytes
  • 纯化方式

    Protein G
  • 浓度

    50 μg/ml
  • 标记

    Pacific Blue
  • 性状

    Liquid
  • 缓冲体系

    PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300

  • 储存条件

    12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

稀释度
应用 稀释度 推荐种属
FCM 5 μl per million cells in 100μl volume Hu
背景介绍
  • CD8α is a crucial immune glycoprotein that plays a vital role in the immune response by serving as a co-receptor for the T-cell receptor (TCR) on cytotoxic T cells. It forms either a homodimer (α/α) or a heterodimer with CD8β (α/β) to interact with MHC class I molecules on antigen-presenting cells (APCs), facilitating the recognition of intracellular pathogens such as viruses. CD8α also recruits the LCK kinase, which initiates downstream signaling pathways essential for T-cell activation and proliferation. This molecule is critical for the function of cytotoxic T lymphocytes (CTLs) and is involved in various immune-related diseases, including immunodeficiencies and autoimmune conditions.

  • 流式分析

    • Flow cytometric analysis of Human CD8 expression on human peripheral blood lymphocytes. Human peripheral blood lymphocytes were stained with Alexa Fluor® 647 Mouse Anti-Human CD3 Antibody and either Mouse IgG1 Isotype Control (Left panel) or SDT Pacific Blue™ Mouse Anti-Human CD8 Antibody (Right panel) at 5 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.