PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| FCM | 5μl per million cells in 100μl volume | Rt |
CD25, also known as the interleukin-2 receptor alpha chain (IL-2Rα), is a membranous glycoprotein that forms the alpha chain of the IL-2 receptor complex. It is primarily expressed on activated T lymphocytes and plays a crucial role in regulating immune responses by mediating IL-2 signaling. When combined with IL-2Rβ and the common γ chain, CD25 forms a high-affinity receptor complex that enhances the binding and signaling of IL-2, promoting T-cell proliferation and activation. Additionally, CD25 is involved in the development and function of regulatory T cells, which help maintain immune tolerance and prevent autoimmune diseases. Abnormal expression of CD25 has been associated with various diseases, including autoimmune disorders and certain cancers, making it a potential target for therapeutic interventions.
Flow cytometric analysis of SD Rat splenocytes treated 4h with 10μg/ml LPS (Right panel) or untreated (Left panel) was stained with Alexa Fluor® 488 Mouse Anti-Rat CD4 Antibody and SDT Alexa Fluor® 647 Mouse Anti-Rat CD25 Antibody at 5μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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