PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| FCM | 5μl per million cells in 100μl volume | Ms |
CD140a, also known as Platelet-Derived Growth Factor Receptor Alpha (PDGFRα), is a cell surface receptor tyrosine kinase that plays a crucial role in various biological processes. It is a member of the receptor tyrosine kinase (RTK) III class and is widely expressed in cells of mesenchymal origin, including fibroblasts, endothelial cells, glial cells, and certain tumor cells. CD140a binds to various isoforms of platelet-derived growth factors (PDGFs) such as PDGF-AA, PDGF-AB, and PDGF-BB, forming homodimers or heterodimers with CD140b (PDGFRβ) to mediate cellular responses. This receptor is involved in cell proliferation, differentiation, migration, and survival, and is essential for embryonic development, wound healing, and the regulation of platelet activation.
Flow cytometric analysis of Mouse CD140a expression on NIH/3T3. NIH/3T3 (Mouse embryonic fibroblast) was stained with Alexa Fluor® 647 Rat IgG2a, κ Isotype Control (Black line histogram) or SDT Alexa Fluor® 647 Rat Anti-Mouse CD140a Antibody (Red line histogram) at 5μl/test, cells without incubation with primary antibody and secondary antibody (Blue line histogram) was used as unlabelled control. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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