PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
12 months from date of receipt / reconstitution, -20 °C as supplied
| 应用 | 稀释度 | 推荐种属 |
|---|---|---|
| WB | 1:1000 | Hu |
Cytochrome P450 17A1 (CYP17A1) is a critical enzyme in human steroidogenesis, responsible for producing essential hormones such as glucocorticoids, androgens, and estrogens. It is a dual-function monooxygenase with both 17α-hydroxylase and 17,20-lyase activities. The 17α-hydroxylase activity converts pregnenolone to 17α-hydroxypregnenolone, while the 17,20-lyase activity cleaves carbon-carbon bonds to produce androgens like dehydroepiandrosterone (DHEA). CYP17A1 is located on chromosome 10q24.3 and is a member of the cytochrome P450 superfamily, which are known for their role in catalyzing various metabolic processes. Mutations in the CYP17A1 gene can lead to disorders such as congenital adrenal hyperplasia and sex development abnormalities due to impaired steroid hormone synthesis. Additionally, CYP17A1 is a therapeutic target in prostate cancer treatment, as it plays a role in androgen synthesis, which can drive cancer growth.
WB result of CYP17A1 Recombinant Rabbit mAb
Primary antibody: CYP17A1 Recombinant Rabbit mAb at 1/1000 dilution
Lane 1: A549 whole cell lysate 20 µg
Lane 2: HeLa whole cell lysate 20 µg
Lane 3: Jurkat whole cell lysate 20 µg
Lane 4: SK-OV-3 whole cell lysate 20 µg
Lane 5: HepG2 whole cell lysate 20 µg
Secondary antibody: Goat Anti-rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
Predicted MW: 57 kDa
Observed MW: 57 kDa
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